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CYCLIN-DEPENDENT KINASE INHIBITOR P27
Descriptors Found:
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DeCS
Descriptor
English
:
Cyclin-Dependent Kinase Inhibitor p27
Descriptor
Spanish
:
Inhibidor p27 de las Quinasas Dependientes de la Ciclina
Descriptor
Portuguese
:
Inibidor de Quinase Dependente de Ciclina p27
Synonyms
English
:
CDK Inhibitor p27
CDK Inhibitor, p27
CDKN1B Protein
CDKN4 Protein
Cyclin Dependent Kinase Inhibitor 1B
Cyclin Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinase Inhibitor 1B
Kip1 Protein, p27
p27 CDK Inhibitor
p27 Kip1 Protein
p27, CDK Inhibitor
p27Kip1 Protein
Tree Number:
D12.644.360.225.600
D12.776.167.187.600
D12.776.476.225.600
D12.776.624.776.355.600
Definition
English
:
A cyclin-dependent kinase inhibitor that coordinates the activation of
CYCLIN
and
CYCLIN-DEPENDENT KINASES
during the
CELL CYCLE
. It interacts with active
CYCLIN D
complexed to
CYCLIN-DEPENDENT KINASE 4
in proliferating cells, while in arrested cells it binds and inhibits
CYCLIN E
complexed to
CYCLIN-DEPENDENT KINASE 2.
Pharmacological Action:
Protein Kinase Inhibitors
History Note
English
:
2006(1992)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50932
Unique Identifier:
D050760
Occurrence in VHL
:
Similar:
DeCS